A case of CNS metastasis from gastric MALT lymphoma

Recently, the incidence of primary CNS lymphoma (PCNSL) is increasing. Metastatic CNS lymphoma occurs much less than PCNSL. We report the case of a 53-year-old man who presented with CNS metastasis from gastric mucosa-associated lymphoid tissue (MALT) lymphoma. The symptoms at the time of diagnosis...

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Bibliographic Details
Published inNō shinkei geka Vol. 37; no. 12; p. 1235
Main Authors Arai, Atsushi, Taomoto, Katsushi, Yokoyama, Masato, Kudo, Hiroshi, Nishisaki, Hogara, Kajimoto, Kazuyoshi
Format Journal Article
LanguageJapanese
Published Japan 01.12.2009
Subjects
Brain Neoplasms - pathology
Helicobacter Infections - complications
Humans
Lymphoma, B-Cell, Marginal Zone - pathology
Male
Middle Aged
Stomach Neoplasms - pathology
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Summary:Recently, the incidence of primary CNS lymphoma (PCNSL) is increasing. Metastatic CNS lymphoma occurs much less than PCNSL. We report the case of a 53-year-old man who presented with CNS metastasis from gastric mucosa-associated lymphoid tissue (MALT) lymphoma. The symptoms at the time of diagnosis were dizziness and aphasia. MRI revealed a left parietal lobe tumor with a large peritumoral edema. About 4 years ago, he had suffered from gastric MALT lymphoma with a high grade component. Eradication of Helicobacter pylori led to remission of the disease 18 months after the treatment. From his past history, the brain tumor was suspected of being a metastatic lymphoma. Stereotactic biopsy revealed diffuse large B-cell lymhoma. Histopathological findings including lymphocytic subsets were almost identical between the primary gastric MALT lymphoma and metastatic brain lymphoma. Complete remission was obtained by repeated high-dose methotrexate chemotherapy. There has been no recurrence for 5 years without additional therapy. This case is probably the first report of CNS metastasis from gastric MALT lymphoma.
ISSN:0301-2603