Clinical evaluation of vulvar lichen sclerosus: case series

Vulvar lichen sclerosus is a chronic dermatitis which is located in labial, perineal and perianal areas. The etiology of lichen sclerosus is multifactorial including genetic, autoimmune, hormonal and infectious aspects. A retrospective analysis was carried out of the medical records of 82 patients w...

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Published inEuropean journal of gynaecological oncology Vol. 31; no. 5; p. 555
Main Authors Kazandi, M, Sahin, C, Terek, M C, Cirpan, T, Oztekin, K
Format Journal Article
LanguageEnglish
Published Italy 2010
Subjects
Administration, Topical
Adrenal Cortex Hormones - administration & dosage
Adult
Aged
Clobetasol - administration & dosage
Cohort Studies
Drug Administration Schedule
Female
Humans
Middle Aged
Retrospective Studies
Vulvar Lichen Sclerosus - drug therapy
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Summary:Vulvar lichen sclerosus is a chronic dermatitis which is located in labial, perineal and perianal areas. The etiology of lichen sclerosus is multifactorial including genetic, autoimmune, hormonal and infectious aspects. A retrospective analysis was carried out of the medical records of 82 patients who were suffering from pruritus vulva. All patients had vulvar biopsy-proven diagnosis of lichen sclerosus. Sixty-six of patients (80.4%) were in the postmenopausal period and 16 patients (19.5%) were in the premenopausal phase. Fifteen patients (18.2%) had thyroid disease, six had (7.3%) diabetes mellitus, five had (6.09%) asthma and five patients had (6.09%) other autoimmune diseases. Lichen sclerosus was most commonly located on the labia majora--58 cases (70.7%). Sixty-four patients (78.04%) had used only potent corticosteroid therapy as the sole treatment. The first-line treatment is topical-potent or ultra-potent corticosteroids in the treatment of lichen sclerosis. Vulvar lichen sclerosis may be associated with autoimmune and thyroid diseases.
ISSN:0392-2936