Antioxidant and hepatoprotective effect of the ethyl acetate extract of Enicostemma axillare (Lam). Raynal against CCL4-induced liver injury in rats

Enicostemma axillare is used in Indian traditional medicine as a liver tonic. Its ethyl acetate extract has shown potent in vitro antioxidant activity and found to contain 7.26% of a bitter secoiridoid glycoside, swertiamarin. Hence, in the present study the ethyl acetate extract was screened for he...

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Published inIndian journal of experimental biology Vol. 48; no. 9; pp. 896 - 904
Main Authors Jaishree, V, Badami, Shrishailappa, Krishnamurthy, Praveen Thaggikuppe
Format Journal Article
LanguageEnglish
Published India 01.09.2010
Subjects
Acetates - chemistry
Animals
Antioxidants - pharmacology
Antioxidants - therapeutic use
Carbon Tetrachloride
Chromatography, Thin Layer
Gentianaceae - chemistry
Kidney - drug effects
Kidney - pathology
Liver - drug effects
Liver - pathology
Liver Diseases - drug therapy
Liver Diseases - pathology
Male
Phytotherapy
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Protective Agents - pharmacology
Protective Agents - therapeutic use
Rats
Rats, Wistar
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Summary:Enicostemma axillare is used in Indian traditional medicine as a liver tonic. Its ethyl acetate extract has shown potent in vitro antioxidant activity and found to contain 7.26% of a bitter secoiridoid glycoside, swertiamarin. Hence, in the present study the ethyl acetate extract was screened for hepatoprotective and antioxidant properties against CCl4 induced hepatic injury in rats. The hepatoprotection was assessed in terms of reduction in histological damage and changes in serum enzymes and metabolites. The pretreatment with the extract at 100 and 200 mg/kg body weight doses given orally for eight days prior to CCl4 caused significant restoration of altered biochemical changes due to CCl4 towards the normal in serum, liver and kidney. The extract treatment at 200 mg/kg body weight was found to be more potent than the standard silymarin at 100 mg/kg body weight in reversing most of the biochemical parameters. Histopathological studies complemented the results of biochemical estimations in providing a proof of hepatoprotective and antioxidant actions of the extract. The study provides a support to the ethnomedical use of E. axillare in India.
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ISSN:0019-5189