Analysis of an ophthalmic pathology cohort of human fetal eyes with regard to interesting findings

• Published in: Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft Vol. 107; no. 11; pp. 1051 - 1058
• Main Authors: Herwig, M C, Müller, A M, Holz, F G, Loeffler, K U
• Format: Journal Article
• Language: German
• Published: Germany 01.11.2010
• Subjects: Abnormalities, Multiple - embryology; Abnormalities, Multiple - genetics; Abnormalities, Multiple - pathology; Eye - embryology; Eye - pathology; Eye Abnormalities - embryology; Eye Abnormalities - genetics; Eye Abnormalities - pathology; Female; Fetal Diseases - genetics; Fetal Diseases - pathology; Gestational Age; Humans; Male; Pregnancy; Retina - abnormalities; Retina - pathology; Syndrome
• ISSN: 1433-0423
• DOI: 10.1007/s00347-010-2174-z

Information on the evaluation of prenatal ocular findings is sparse. This article provides an overview of the morphology in a cohort of human fetal eyes, with particular emphasis on interesting findings. The study investigated 216 eyes from 115 human fetuses. The majority of fetal eyes presented with a regular phenotype. Rarely, unexpected findings were discovered in fetuses with or without systemic malformations. Routine evaluation of fetal eyes reveals-albeit rarely-new aspects providing further knowledge and occasionally enabling the exact classification of syndromes.