Epididymo-orchitis and central nervous system nocardiosis in a bone marrow transplant recipient for acute lymphoblastic leukemia

• Published in: Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation Vol. 7; no. 4; pp. 264 - 266
• Main Authors: Dehghani, Mehdi, Dehghani, Seyed Mohsen, Davarpanah, Mohammad-Ali
• Format: Journal Article
• Language: English
• Published: Turkey 01.12.2009
• Subjects: Acute Disease; Anti-Infective Agents - therapeutic use; Bone Marrow Transplantation - adverse effects; Brain Abscess - diagnosis; Brain Abscess - drug therapy; Brain Abscess - microbiology; Chronic Disease; Epididymitis - drug therapy; Epididymitis - microbiology; Epilepsy, Tonic-Clonic - microbiology; Fatal Outcome; Graft vs Host Disease - etiology; Humans; Immunosuppressive Agents - adverse effects; Magnetic Resonance Imaging; Male; Nocardia Infections - diagnosis; Nocardia Infections - drug therapy; Nocardia Infections - microbiology; Orchitis - drug therapy; Orchitis - microbiology; Pancytopenia - etiology; Precursor Cell Lymphoblastic Leukemia-Lymphoma - surgery; Trimethoprim, Sulfamethoxazole Drug Combination - therapeutic use; Young Adult
• ISSN: 2146-8427

We report a case of epididymo-orchitis and central nervous system nocardiosis in a 22-year-old man with T-cell acute lymphoblastic leukemia; he was an allogeneic marrow recipient with acute and chronic graft-versus-host disease. He had microscopic hematuria and cytomegalovirus antigenemia. He deteriorated subsequently while on cyclosporine and steroids, requiring hospital admission owing to fever and swelling of the left testis and generalized tonic-clonic convulsions. Brain magnetic resonance imaging showed abnormal signal area in right parietal and left parieto-occipital lobes. The lesions had mass effect, edema, and ring enhancement. Findings were indicative of a brain abscess. A testicular biopsy from the lower pole of the left testis was done. A white-to-yellowish discharge was seen and subsequently, Nocardia grew in culture. Trimethoprim-sulfamethoxazole was prescribed, and significant improvement was seen after 2 weeks. The patient was discharged. He was subsequently referred after 3 weeks due to graft-versus-host disease and died of pancytopenia.