NSAID-induced colopathy. A case series

• Published in: Journal of gastrointestinal and liver diseases : JGLD Vol. 19; no. 1; pp. 89 - 91
• Main Authors: Aftab, Abdur R, Donnellan, Fergal, Zeb, Faisal, Kevans, David, Cullen, Garret, Courtney, Garry
• Format: Journal Article
• Language: English
• Published: Romania 01.03.2010
• Subjects: Aged; Anemia, Iron-Deficiency - chemically induced; Anemia, Iron-Deficiency - diagnosis; Anti-Inflammatory Agents, Non-Steroidal - adverse effects; Biopsy; Colon - drug effects; Colon - pathology; Colonic Diseases - chemically induced; Colonic Diseases - diagnosis; Colonoscopy; Diarrhea - chemically induced; Diarrhea - diagnosis; Diclofenac - adverse effects; Disease Progression; Female; Gastrointestinal Hemorrhage - chemically induced; Gastrointestinal Hemorrhage - diagnosis; Humans; Middle Aged; Time Factors
• ISSN: 1841-8724

The adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs) on the upper gastrointestinal tract and small intestine are well established. The effect of such therapy on the large intestine, so called NSAID colopathy, is less well described. We present four such cases demonstrating the characteristic endoscopic findings. One case in particular is, to our knowledge, the first report of the natural history of this clinical entity, initially presenting with the acute picture of inflammation and ulceration with subsequent progression to the more chronic development of diaphragm-like fibrous strictures. NSAID-induced colonic damage is a clinically significant condition. Two of our patients presented with bloody diarrhoea while the other two patients developed symptomatic anaemia. With the increasing use of enteric coated and sustained release NSAID preparations this condition is likely to become more frequent. Increasing awareness of its clinical presentation and of its spectrum of endoscopic findings facilitates a more prompt diagnosis and appropriate treatment to be established.