Metastasis of high grade renal cell carcinoma, clear cell type, in fibrous dysplasia with superimposed giant cell reparative granuloma

A case of monostotic fibrous dysplasia in a 54-year-old male complaining of severe pain in the right hip is presented. Imaging findings demonstrated an extremely aggressive lesion involving bones, liver, lungs, and lymph nodes, and suggested the possibility of sarcomatous transformation. Histologica...

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Bibliographic Details
Published inPathologica Vol. 101; no. 6; p. 240
Main Authors Rizzardi, C, Schneider, M, Barresi, E, Brollo, A, Melato, M
Format Journal Article
LanguageEnglish
Published Italy 01.12.2009
Subjects
Bone Neoplasms - secondary
Carcinoma, Renal Cell - secondary
Fibrous Dysplasia, Monostotic - complications
Fibrous Dysplasia, Monostotic - pathology
Granuloma, Giant Cell - complications
Granuloma, Giant Cell - pathology
Humans
Immunohistochemistry
Kidney Neoplasms - pathology
Male
Middle Aged
Radionuclide Imaging
Tomography, X-Ray Computed
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Summary:A case of monostotic fibrous dysplasia in a 54-year-old male complaining of severe pain in the right hip is presented. Imaging findings demonstrated an extremely aggressive lesion involving bones, liver, lungs, and lymph nodes, and suggested the possibility of sarcomatous transformation. Histological examination established a diagnosis of metastatic high-grade renal carcinoma, clear cell type, and demonstrated the presence of superimposed giant cell reparative granuloma. This latter is a rare example of giant cell reparative granuloma arising in a long bone and in association with fibrous dysplasia. The clinical, radiographic, and histopathologic features of fibrous dysplasia and giant cell reparative granuloma are discussed.
ISSN:0031-2983