Angioedema in a 47-year-old woman with hypocomplementemic urticarial vasculitis syndrome

Hypocomplementemic urticarial vasculitis syndrome (HUVS) is a type III hypersensitivity reaction characterized by urticaria with persistent acquired hypocomplementemia. Although HUVS is uncommon, it is important for physicians to be familiar with this disease, as the initial presentation is often li...

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Bibliographic Details
Published inThe Journal of the American Osteopathic Association Vol. 112; no. 2; pp. 90 - 92
Main Authors Jones, Julie M, Reich, Keith A, Raval, Deena G
Format Journal Article
LanguageEnglish
Published United States 01.02.2012
Subjects
Angioedema - diagnosis
Angioedema - drug therapy
Angioedema - immunology
Autoantibodies - analysis
Complement System Proteins - deficiency
Epinephrine - therapeutic use
Female
Humans
Infusions, Intravenous
Methylprednisolone Hemisuccinate - administration & dosage
Middle Aged
Rare Diseases
Risk Assessment
Severity of Illness Index
Syndrome
Treatment Outcome
Urticaria - diagnosis
Urticaria - immunology
Vasculitis - diagnosis
Vasculitis - immunology
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Summary:Hypocomplementemic urticarial vasculitis syndrome (HUVS) is a type III hypersensitivity reaction characterized by urticaria with persistent acquired hypocomplementemia. Although HUVS is uncommon, it is important for physicians to be familiar with this disease, as the initial presentation is often life-threatening angioedema. The author reports the case of a 47-year-old white woman with a history of HUVS. She presented to an outpatient clinic complaining of a rash and difficulty swallowing. Urticaria and angioedema were diagnosed. The patient was given epinephrine in the clinic and then transferred to the hospital. Laboratory testing confirmed urticaria, and the patient was given intravenous methylprednisolone sodium succinate and an additional dose of epinephrine. After 1 week, the patient's angioedema improved.
Bibliography:ObjectType-Case Study-2
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ISSN:1945-1997