Simultaneous occurrence of synchronous and metachronous tumors with gastrointestinal stromal tumors

To examine the frequency and clinicopathological features of synchronous and metachronous tumors which occur simultaneously with gastrointestinal stromal tumors (GIST). Clinical and pathologic records of 78 patients diagnosed with primary GIST and treated at our institution between 1997 and 2009 wer...

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Published inBratislavské lékarské listy Vol. 112; no. 11; p. 623
Main Authors Adim, S B, Filiz, G, Kanat, O, Yerci, O
Format Journal Article
LanguageEnglish
Published Slovakia 2011
Subjects
Adult
Aged
Female
Gastrointestinal Neoplasms - pathology
Gastrointestinal Stromal Tumors - pathology
Humans
Male
Middle Aged
Neoplasms, Multiple Primary - pathology
Neoplasms, Second Primary - pathology
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Summary:To examine the frequency and clinicopathological features of synchronous and metachronous tumors which occur simultaneously with gastrointestinal stromal tumors (GIST). Clinical and pathologic records of 78 patients diagnosed with primary GIST and treated at our institution between 1997 and 2009 were reviewed. GIST occurred simultaneously with other primary GI malignancies in 16.1 % (n = 13) of all patients with GIST. Of the simultaneous secondary tumors, 69.2 % (n = 9) were gastrointestinal tumors, and the remaining were biliary system and breast tumors. GIST most frequently had gastric localization (n = 6, 46.1%). Although GIST are uncommon neoplasms, their synchronous and metachronous coexistence with other tumors is rather frequent, mostly as incidental tumors accompanying a gastrointestinal neoplasm. Therefore, during surgery on cases with gastrointestinal neoplasms, the surgeon needs to be careful about a synchronous GIST. At the same time, more detailed studies are needed about the carcinogenesis of dual tumors coexisting with GIST (Tab. 1, Ref. 14).
ISSN:0006-9248