Five year prognosis of an Italian cohort of juvenile acute myocardial infarction patients

The aim of this study was to describe the five-year prognosis of an Italian cohort of patients following acute myocardial infarction (AMI) occurred at age ≤ 45 years and to investigate the potential role of risk predictors for future cardiovascular events (CVE). The study enrolled 112 consecutive pa...

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Bibliographic Details
Published inMinerva cardioangiologica Vol. 58; no. 4; p. 433
Main Authors Fornengo, C, Anselmino, M, Iacovino, C, Palumbo, L, Trevi, G P, Bergerone, S
Format Journal Article
LanguageEnglish
Published Italy 01.08.2010
Subjects
Acute Disease
Adolescent
Adult
Cohort Studies
Coronary Vessels - pathology
Electrocardiography
Female
Follow-Up Studies
Humans
Italy
Life Style
Male
Middle Aged
Motor Activity
Myocardial Infarction - diagnosis
Myocardial Infarction - epidemiology
Prognosis
Proportional Hazards Models
Recurrence
Risk Factors
Young Adult
Italy
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Summary:The aim of this study was to describe the five-year prognosis of an Italian cohort of patients following acute myocardial infarction (AMI) occurred at age ≤ 45 years and to investigate the potential role of risk predictors for future cardiovascular events (CVE). The study enrolled 112 consecutive patients aged ≤ 45 years admitted to our Coronary Care Unit between March 1995 and January 2007 because of AMI. Clinical characteristics, extent of coronary vessel disease by angiogram and cardiovascular risk factors (including diet, physical activity, alcohol and coffee consumption) were registered. Complete follow-up data was available for 104 (93%) patients with a duration of follow-up of 5.3 (2.9-7.6) years. Twenty-four (23%) patients presented with a new CVE: 16 (15%) angina pectoris, 6 (6%) recurrent AMI, one heart failure and one cardiac death. One in every five patients presented left ventricle systolic function below 50%. Multivariate analysis (Cox proportional regression model) proved physical activity as an independent predictor of new CVE occurrence (P=0.014). Patients who practised moderate aerobic physical activity for at least two hours per week following AMI had significantly higher event-free survival compared with inactive controls (P=0.029). Five-year prognosis of juvenile AMI is poor, with one in every five patients presenting a new CVE. Based on the present cohort of patients physical activity following first event plays a relevant prognostic role, supporting the need of careful lifestyle counselling.
ISSN:0026-4725