Therapeutic drug monitoring of lopinavir in human immunodeficiency virus-infected children receiving adult tablets

Because of the lack of a lopinavir/ritonavir (LPV/r) pediatric formulation, 54 HIV-infected children were given generic LPV/r adult tablets. Of 54 children, 21 took cut pills to get the appropriate dose. The median (interquartile range) LPV trough serum concentration (C trough) was 6.7 (5.0-9.9) mg/...

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Bibliographic Details
Published inThe Pediatric infectious disease journal Vol. 29; no. 1; p. 79
Main Authors Puthanakit, Thanyawee, Chokephaibulkit, Kulkanya, Suntarattiwong, Piyarat, Gorowara, Meena, Leawsrisuk, Pimsiri, Suwanlerk, Tulathip, Boonrak, Pitch, Ruxrungtham, Kiat
Format Journal Article
LanguageEnglish
Published United States 01.01.2010
Subjects
Adolescent
Child
Drug Monitoring
HIV Infections - drug therapy
Humans
Lopinavir
Pyrimidinones - administration & dosage
Pyrimidinones - therapeutic use
Serum - chemistry
Tablets - administration & dosage
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Summary:Because of the lack of a lopinavir/ritonavir (LPV/r) pediatric formulation, 54 HIV-infected children were given generic LPV/r adult tablets. Of 54 children, 21 took cut pills to get the appropriate dose. The median (interquartile range) LPV trough serum concentration (C trough) was 6.7 (5.0-9.9) mg/L. All the children had C trough >1.0 mg/L and 96% had values >4.0 mg/L. LPV/r adult tablets can be used in children when it is necessary.
ISSN:1532-0987
DOI:10.1097/INF.0b013e3181b21040