Application of RNA-seq to reveal the transcript profile in bacteria

The large number of microbial genomes deposited in databanks has opened the door for in-depth studies of organisms, including post-genomics investigations. Thanks to new generation sequencing technology, these studies have made advances that have lead to extraordinary discoveries in bacterial transc...

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Bibliographic Details
Published inGenetics and molecular research Vol. 10; no. 3; pp. 1707 - 1718
Main Authors Pinto, A C, Melo-Barbosa, H P, Miyoshi, A, Silva, A, Azevedo, V
Format Journal Article
LanguageEnglish
Published Brazil 2011
Subjects
Bacteria - genetics
Base Sequence
Genome, Bacterial
RNA, Bacterial - chemistry
RNA, Bacterial - genetics
Sequence Analysis, RNA - methods
Transcriptome
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Summary:The large number of microbial genomes deposited in databanks has opened the door for in-depth studies of organisms, including post-genomics investigations. Thanks to new generation sequencing technology, these studies have made advances that have lead to extraordinary discoveries in bacterial transcriptomics. In this review, we describe bacterial RNA sequencing studies that use these new techniques. We also examined the advantages and biases of these new generation technologies; advances in bioinformatics make it possible to overcome the biases, providing interesting and surprising results.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
ISSN:1676-5680
DOI:10.4238/vol10-3gmr1554