Adhesion molecules in cancer of the head and neck: role of dysadherin

Dysadherin is a recently discovered cancer-related cell membrane glycoprotein that has an important role in tumor progression and metastasis. We are focusing on the role of dysadherin in E-cadherin downregulation, the different expression patterns of the molecule in cancer of the head and neck and i...

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Bibliographic Details
Published inJournal of B.U. ON. Vol. 16; no. 4; p. 609
Main Authors Giotakis, I, Chrysovergis, A, Georgolios, A, Giotakis, E, Manolopoulos, L
Format Journal Article
LanguageEnglish
Published Greece 01.10.2011
Subjects
Cadherins - biosynthesis
Cadherins - metabolism
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - pathology
Cell Adhesion - physiology
Cell Adhesion Molecules - metabolism
Female
Head and Neck Neoplasms - metabolism
Head and Neck Neoplasms - pathology
Humans
Male
Membrane Glycoproteins - metabolism
Neoplasm Proteins - metabolism
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Summary:Dysadherin is a recently discovered cancer-related cell membrane glycoprotein that has an important role in tumor progression and metastasis. We are focusing on the role of dysadherin in E-cadherin downregulation, the different expression patterns of the molecule in cancer of the head and neck and its potential role as a molecular target for future applications in diagnosis, prognosis, and management of the disease.
ISSN:1107-0625