Perioperative analgesia of infants during the therapy for retinopathy of prematurity

In this retrospective investigation, we compared the main anesthesiologic aspects in the preoperative, perioperative, and postoperative care of 2 different surgical methods (cryotherapy, laser coagulation) for retinopathy of prematurity. A retrospective analysis of analgesia for retinopathy of prema...

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Published inMedical science monitor Vol. 16; no. 4; pp. CR186 - CR189
Main Authors Görbe, Eva, Vámos, Rita, Joó, Gabor József, Jeager, Judit, Molvarec, Attila, Berecz, Botond, Horváth, Adrienn, Sulya, Balint, Rigó, Jr, János
Format Journal Article
LanguageEnglish
Published United States 01.04.2010
Subjects
Analgesia - methods
Anesthesiology - methods
Cryotherapy - methods
Diazepam - therapeutic use
Humans
Infant
Infant, Newborn
Ketamine - therapeutic use
Laser Coagulation - methods
Lasers
Nalbuphine - therapeutic use
Postoperative Period
Preoperative Period
Retinopathy of Prematurity - therapy
Retrospective Studies
Treatment Outcome
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Summary:In this retrospective investigation, we compared the main anesthesiologic aspects in the preoperative, perioperative, and postoperative care of 2 different surgical methods (cryotherapy, laser coagulation) for retinopathy of prematurity. A retrospective analysis of analgesia for retinopathy of prematurity was performed for a 14-year period. Infants treated from January 1994 to December 2007 were involved in the study. Before 1997, we performed transconjunctival cryotherapy with ketamine analgesia for 28 newborn infants, while in the last 10 years, laser photocoagulation was done with nalbuphine-diazepam analgesia in 85 cases. Significant differences were verified in gestational age of birth in the group of retinopathy of prematurity patients treated with cryotherapy compared with those treated with laser coagulation 27.9+/-2.7 weeks vs 26.4+/-2.4 weeks (P<.05). The difference in the need for postoperative ventilation (43% vs 19%; P<.05) as well as the number of cases with hypoxemia (54% vs 21%; P<.05) was significant, compared with the group of infants treated with cryotherapy with those treated with laser coagulation. This study demonstrates that intravenous analgesia (with ketamine or nalbuphine-diazepam) can be used in the surgical treatment of retinopathy of prematurity.
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ISSN:1643-3750