Diffuse alveolar damage

Diffuse alveolar damage (DAD) is a characteristic histopathologic pattern that has time dependent findings: intraalveolar and interstitial oedema, and hyaline membranes in the acute phase, myofibroblastic accumulation in the alveolar spaces and type II alveolar cell proliferation in the proliferativ...

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Bibliographic Details
Published inPathologica Vol. 102; no. 6; p. 453
Main Authors Poletti, V, Casoni, G L, Cancellieri, A, Piciucchi, S, Dubini, A, Zompatori, M
Format Journal Article
LanguageEnglish
Published Italy 01.12.2010
Subjects
Acute Lung Injury - etiology
Acute Lung Injury - pathology
Acute Lung Injury - physiopathology
Biopsy
Bronchoalveolar Lavage
Bronchoscopy - methods
Disease Progression
Humans
Lung Diseases, Interstitial - diagnosis
Lung Diseases, Interstitial - etiology
Lung Diseases, Interstitial - physiopathology
Pulmonary Alveoli - pathology
Pulmonary Alveoli - physiopathology
Respiratory Insufficiency - etiology
Respiratory Insufficiency - pathology
Respiratory Insufficiency - physiopathology
Time Factors
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Summary:Diffuse alveolar damage (DAD) is a characteristic histopathologic pattern that has time dependent findings: intraalveolar and interstitial oedema, and hyaline membranes in the acute phase, myofibroblastic accumulation in the alveolar spaces and type II alveolar cell proliferation in the proliferative phase and fibrosis in the more advanced phases. The diagnosis of DAD is sometimes feasible on small specimens obtained by transbronchial lung biopsy or on cytological slides. Surgical lung biopsy is rarely needed.
ISSN:0031-2983