Dopamine transporter and D2-receptor density in late-onset alcoholism
Late onset type 1 alcoholism has been suggested to be associated with an underlying dopaminergic defect. Therefore, it is relevant to study both postsynaptic D2-receptor and presynaptic dopamine transporter (DAT) densities among alcoholics. We investigated DAT densities, along with striatal and extr...
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Published in | Psychopharmacologia Vol. 147; no. 3; pp. 314 - 318 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Berlin
Springer
01.12.1999
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | Late onset type 1 alcoholism has been suggested to be associated with an underlying dopaminergic defect. Therefore, it is relevant to study both postsynaptic D2-receptor and presynaptic dopamine transporter (DAT) densities among alcoholics.
We investigated DAT densities, along with striatal and extrastriatal dopamine D2-receptor densities, in nine nonviolent late-onset male alcoholics, who had no major mental disorder nor antisocial personality disorder (ASPD), and nine healthy controls.
[123I]PE2I and [123I]epidepride were used in SPECT imaging.
DAT occupancy ratios (striatum/cerebellum) were significantly lower among alcoholics than in controls. Extrastriatal D2-receptor occupancy ratios (temporal pole/cerebellum) were not significantly different between the groups.
Striatal presynaptic DAT densities are decreased among type 1 alcoholics, and this finding is not associated with recent alcohol abuse. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 0033-3158 1432-2072 |
DOI: | 10.1007/s002130051173 |