The impact of total mesorectal excision in middle and low rectal carcinomas

The incidence of locoregional recurrence in rectal cancer has declined since total mesorectal excision (TME) has been widely adopted. The purpose of this study was to investigate the long-term survival and the incidence of locoregional recurrences in patients with middle and low rectal carcinomas un...

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Bibliographic Details
Published inJournal of B.U. ON. Vol. 15; no. 1; p. 56
Main Authors Tentes, A A K, Korakianitis, O S, Veliovic, D, Sgouridou, E, Karagiozoglou, C, Moustakas, K
Format Journal Article
LanguageEnglish
Published Greece 01.01.2010
Subjects
Aged
Carcinoma - mortality
Carcinoma - secondary
Carcinoma - surgery
Chemotherapy, Adjuvant
Digestive System Surgical Procedures - adverse effects
Digestive System Surgical Procedures - mortality
Female
Hospital Mortality
Humans
Kaplan-Meier Estimate
Logistic Models
Male
Middle Aged
Neoplasm Recurrence, Local
Neoplasm Staging
Proctoscopy
Proportional Hazards Models
Radiotherapy, Adjuvant
Rectal Neoplasms - mortality
Rectal Neoplasms - pathology
Rectal Neoplasms - surgery
Retrospective Studies
Risk Assessment
Risk Factors
Sigmoidoscopy
Time Factors
Treatment Outcome
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Summary:The incidence of locoregional recurrence in rectal cancer has declined since total mesorectal excision (TME) has been widely adopted. The purpose of this study was to investigate the long-term survival and the incidence of locoregional recurrences in patients with middle and low rectal carcinomas undergoing TME. The medical records of 126 patients with middle and low rectal carcinomas treated from 1987-2007 were retrospectively reviewed. Of them 80 had undergone total mesorectal excision (TME-group) and 46 surgery with conventional methods (CON-group). Clinical variables were correlated to morbidity, hospital mortality, recurrence, sites of recurrence, and survival. The groups were comparable except for type of surgery and sites of recurrence. Five-year overall survival rate for TME group was 75% and for CON-group 47% (p=0.0346). Although the groups were not different for the total number of recurrences, the number of locoregional recurrences was significantly lower in TME group (p=0.004). TME appears to improve long-term survival in patients with middle and low rectal carcinomas. The incidence of locoregional recurrence is also reduced by TME.
ISSN:1107-0625