Chikungunya virus-associated death in Malaysia

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus which causes fever, rash, and arthralgia. In the past, life-threatening complications were very rarely reported. However, during the recent worldwide outbreaks, there have been several reports of unusually severe complications and deaths. Mala...

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Bibliographic Details
Published inTropical biomedicine Vol. 27; no. 2; pp. 343 - 347
Main Authors Sam, I C, Kamarulzaman, A, Ong, G S Y, Veriah, R S, Ponnampalavanar, S, Chan, Y F, AbuBakar, S
Format Journal Article
LanguageEnglish
Published Malaysia 01.08.2010
Subjects
Alphavirus Infections - epidemiology
Chikungunya Fever
Chikungunya virus - genetics
Fatal Outcome
Humans
Male
Middle Aged
Phylogeny
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Summary:Chikungunya virus (CHIKV) is a mosquito-borne alphavirus which causes fever, rash, and arthralgia. In the past, life-threatening complications were very rarely reported. However, during the recent worldwide outbreaks, there have been several reports of unusually severe complications and deaths. Malaysia is experiencing a nationwide outbreak of CHIKV, with over 10 000 patients affected since April 2008. We report the first case of culture-confirmed CHIKV-associated death in Malaysia, in a patient with fever, rash, acute exacerbation of pre-existing heart failure, rhabdomyolysis, and multiple organ failure. CHIKV infections may cause atypical, severe or fatal presentations.
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ISSN:0127-5720