Replacement of carvedilol for propranolol in patients with heart failure

• Published in: Arquivos brasileiros de cardiologia Vol. 95; no. 1; pp. 107 - 114
• Main Authors: Marques, Fabiana, Castro, Renato Barroso Pereira de, Nobre, Fernando, Pintya, Antonio Osvaldo, Gallo, Jr, Lourenço, Maciel, Benedito Carlos, Simões, Marcus Vinícius
• Format: Journal Article
• Language: English
• Published: Brazil 01.07.2010
• Subjects: Adrenergic beta-Antagonists - therapeutic use; Adult; Carbazoles - therapeutic use; Carvedilol; Drug Substitution; Echocardiography; Follow-Up Studies; Heart Failure - diagnostic imaging; Heart Failure - drug therapy; Humans; Male; Middle Aged; Propanolamines - therapeutic use; Propranolol - therapeutic use; Prospective Studies; Treatment Outcome; Ventricular Function, Left - drug effects
• ISSN: 1678-4170
• DOI: 10.1590/S0066-782X2010005000062

Large clinical trials using the betablockers carvedilol, metoprolol, bisoprolol and nebivolol have demonstrated improvement of survival and symptoms in patients with heart failure. Despite the lack of scientific evidence, it is plausible that their beneficial effects are extensible to other betablockers. To evaluate the impact of the replacement of carvedilol for propranolol on left ventricular function, functional capacity, quality of life, pressure levels, and cardiac autonomic control in patients with heart failure. Twenty nine patients receiving optimized drug therapy including maximum tolerated doses of carvedilol were divided into two groups: replacement of carvedilol for propranolol (n = 15) and continued carvedilol (n = 14). At baseline and 6 months later, clinical and laboratorial assessments were carried out with radionuclide ventriculography, echocardiography, Minnesota questionnaire, walk test, APBM and Holter monitoring. The clinical and demographic characteristics were similar in the two groups at baseline. Individualized propranolol dose adjustment ensured a similar degree of beta-blockade, as assessed by resting heart rate and chronotropic reserve. The mean propranolol dose used was 109 +/- 43 mg/day. Only one patient presented with intolerance to propranolol, thus carvedilol was reintroduced. One death was recorded in group propranolol. Ejection fraction significantly increased in the propranolol group. No significant change was observed in the other cardiovascular variables after betablocker replacement. Our results indicate that replacement of carvedilol for propranolol in patients with heart failure is not associated with deterioration of the ejection fraction, functional capacity, quality of life, and other cardiovascular variables related to autonomic and blood pressure control., PP.0-0).