p53 gene therapy using RNA interference

p53 gene, discovered almost 35 years ago, keeps the main role in cell cycle control, apoptosis pathways and transcription. p53 gene is found mutated in more than 50% of all human cancers in different locations. Many structures from viral to non viral were designed to incorporate and deliver in appro...

Full description

Saved in:
Bibliographic Details
Published inJournal of B.U. ON. Vol. 14 Suppl 1; p. S51
Main Authors Berindan-Neagoe, I, Balacescu, O, Burz, C, Braicu, C, Balacescu, L, Tudoran, O, Cristea, V, Irimie, A
Format Journal Article
LanguageEnglish
Published Greece 01.09.2009
Subjects
Animals
Apoptosis
Cell Cycle - genetics
Cell Division - genetics
Genes, p53
Genes, Tumor Suppressor - physiology
Genetic Therapy - methods
Humans
Models, Genetic
Neoplasms - genetics
Neoplasms - pathology
Neoplasms - therapy
RNA Interference - physiology
Transcription, Genetic
Online AccessGet more information

Cover

More Information
Summary:p53 gene, discovered almost 35 years ago, keeps the main role in cell cycle control, apoptosis pathways and transcription. p53 gene is found mutated in more than 50% of all human cancers in different locations. Many structures from viral to non viral were designed to incorporate and deliver in appropriate conditions forms of p53 gene or its transcripts, systemically to target tumor cells and to eliminate them through apoptosis or to restore the normal tumor suppressor gene role. Each delivery system presents advantages and low performance in relation to immune system recognition and acceptance. One of the major discoveries in the last years, silencing of RNA, represents a powerful tool for inhibiting post transcriptional control of gene expression. According to several studies, the RNA silencing technology for p53 transcripts together with other carriers or transporters at nano level can be used for creating new therapeutic models. RNA interference for p53 uses different double-stranded (ds) molecules like short interfering (si) RNA and, despite the difficulty of introducing them into mammalian cells due to immune system response, it can be exploited in cancer therapy.
ISSN:1107-0625