A model approach to the adaptation of cardiac structure by mechanical feedback in the environment of the cell

The uniformity of the mechanical load of the cardiac fibers in the wall is maintained by continuous remodeling. In this proposed model the myocyte changes direction in optimizing systolic sarcomere shortening. Early systolic stretch and contractility increases the mass of contractile proteins. Cycli...

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Bibliographic Details
Published inAdvances in experimental medicine and biology Vol. 382; p. 217
Main Authors Arts, T, Prinzen, F W, Snoeckx, L H, Reneman, R S
Format Journal Article
LanguageEnglish
Published United States 1995
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Summary:The uniformity of the mechanical load of the cardiac fibers in the wall is maintained by continuous remodeling. In this proposed model the myocyte changes direction in optimizing systolic sarcomere shortening. Early systolic stretch and contractility increases the mass of contractile proteins. Cyclic strain of the myocardial tissue diminishes passive stiffness, resulting in the control of ventricular end-diastolic volume. Utilizing these rules of remodeling in our mathematical model yields that the natural helical pathways of the myocardial fibers in the wall are formed automatically.
ISSN:0065-2598
DOI:10.1007/978-1-4615-1893-8_22