Minireview: 3-Iodothyronamine (T1AM): a new player on the thyroid endocrine team?

3-Iodothyronamine (T(1)AM) is an endogenous compound with chemical features that are similar to thyroid hormone. T(1)AM has a carbon skeleton identical to that of T(4) and contains a single carbon-iodine bond. Theoretically, T(1)AM could be produced from T(4) by enzymatic decarboxylation and deiodin...

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Published inEndocrinology (Philadelphia) Vol. 150; no. 3; p. 1108
Main Author Scanlan, Thomas S
Format Journal Article
LanguageEnglish
Published United States 01.03.2009
Subjects
Animals
Endocrine System - physiology
Humans
Models, Biological
Thyroid Gland - physiology
Thyronines - physiology
Online AccessGet full text
ISSN1945-7170
1945-7170
DOI10.1210/en.2008-1596

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Abstract 3-Iodothyronamine (T(1)AM) is an endogenous compound with chemical features that are similar to thyroid hormone. T(1)AM has a carbon skeleton identical to that of T(4) and contains a single carbon-iodine bond. Theoretically, T(1)AM could be produced from T(4) by enzymatic decarboxylation and deiodination. Recent studies show that T(1)AM and higher iodinated thyronamines are subject to similar metabolic processing as iodothyronines such as T(4), suggesting a biological linkage between iodothyronines and iodothyronamines. In addition, single doses of T(1)AM administered to rodents induce a hypometabolic state that in certain ways resembles hibernation and is opposite to the effects of excess T(4). This review will discuss the latest developments on this recently discovered thyroid hormone derivative.
AbstractList 3-Iodothyronamine (T(1)AM) is an endogenous compound with chemical features that are similar to thyroid hormone. T(1)AM has a carbon skeleton identical to that of T(4) and contains a single carbon-iodine bond. Theoretically, T(1)AM could be produced from T(4) by enzymatic decarboxylation and deiodination. Recent studies show that T(1)AM and higher iodinated thyronamines are subject to similar metabolic processing as iodothyronines such as T(4), suggesting a biological linkage between iodothyronines and iodothyronamines. In addition, single doses of T(1)AM administered to rodents induce a hypometabolic state that in certain ways resembles hibernation and is opposite to the effects of excess T(4). This review will discuss the latest developments on this recently discovered thyroid hormone derivative.3-Iodothyronamine (T(1)AM) is an endogenous compound with chemical features that are similar to thyroid hormone. T(1)AM has a carbon skeleton identical to that of T(4) and contains a single carbon-iodine bond. Theoretically, T(1)AM could be produced from T(4) by enzymatic decarboxylation and deiodination. Recent studies show that T(1)AM and higher iodinated thyronamines are subject to similar metabolic processing as iodothyronines such as T(4), suggesting a biological linkage between iodothyronines and iodothyronamines. In addition, single doses of T(1)AM administered to rodents induce a hypometabolic state that in certain ways resembles hibernation and is opposite to the effects of excess T(4). This review will discuss the latest developments on this recently discovered thyroid hormone derivative.
3-Iodothyronamine (T(1)AM) is an endogenous compound with chemical features that are similar to thyroid hormone. T(1)AM has a carbon skeleton identical to that of T(4) and contains a single carbon-iodine bond. Theoretically, T(1)AM could be produced from T(4) by enzymatic decarboxylation and deiodination. Recent studies show that T(1)AM and higher iodinated thyronamines are subject to similar metabolic processing as iodothyronines such as T(4), suggesting a biological linkage between iodothyronines and iodothyronamines. In addition, single doses of T(1)AM administered to rodents induce a hypometabolic state that in certain ways resembles hibernation and is opposite to the effects of excess T(4). This review will discuss the latest developments on this recently discovered thyroid hormone derivative.
Author Scanlan, Thomas S
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References 16131330 - Thyroid. 2005 Aug;15(8):875-81
17992256 - J Clin Invest. 2007 Dec;117(12):4034-43
4152982 - J Theor Biol. 1974 Jul;46(1):255-70
5351077 - Pharmacology. 1969;2(5):281-7
17016550 - J Clin Invest. 2006 Oct;116(10):2571-9
17530732 - ACS Chem Biol. 2007 Jun 15;2(6):390-8
4715216 - Eur J Pharmacol. 1973 May;22(2):141-9
16451074 - J Med Chem. 2006 Feb 9;49(3):1101-12
17690312 - Stroke. 2007 Sep;38(9):2569-76
11898402 - Methods Enzymol. 2002;347:125-67
17088868 - Br J Pharmacol. 2006 Dec;149(8):967-78
4380584 - Med Pharmacol Exp Int J Exp Med. 1966;15(1):17-23
18420141 - Chem Biol. 2008 Apr;15(4):343-53
15146179 - Nat Med. 2004 Jun;10(6):638-42
14887111 - C R Seances Soc Biol Fil. 1951 Jun;145(11-12):797-800
17912534 - J Comp Physiol B. 2008 Feb;178(2):167-77
18339710 - Endocrinology. 2008 Jun;149(6):3037-45
13319281 - J Biol Chem. 1956 Apr;219(2):595-604
4457225 - Cardiovasc Res. 1974 Nov;8(6):721-30
6319258 - Horm Metab Res. 1983 Dec;15(12):602-6
17204552 - Endocrinology. 2007 Apr;148(4):1921-7
17284482 - FASEB J. 2007 May;21(7):1597-608
18486124 - Eur J Pharmacol. 2008 Jun 10;587(1-3):231-6
18823891 - J Chromatogr A. 2008 Nov 7;1210(1):55-9
18752950 - Bioorg Med Chem Lett. 2008 Nov 15;18(22):5920-2
11427693 - Physiol Rev. 2001 Jul;81(3):1097-142
19105176 - Chembiochem. 2009 Jan 26;10(2):361-5
17497842 - J Med Chem. 2007 Jun 14;50(12):2787-98
References_xml – reference: 16451074 - J Med Chem. 2006 Feb 9;49(3):1101-12
– reference: 15146179 - Nat Med. 2004 Jun;10(6):638-42
– reference: 18486124 - Eur J Pharmacol. 2008 Jun 10;587(1-3):231-6
– reference: 17088868 - Br J Pharmacol. 2006 Dec;149(8):967-78
– reference: 13319281 - J Biol Chem. 1956 Apr;219(2):595-604
– reference: 16131330 - Thyroid. 2005 Aug;15(8):875-81
– reference: 17497842 - J Med Chem. 2007 Jun 14;50(12):2787-98
– reference: 4457225 - Cardiovasc Res. 1974 Nov;8(6):721-30
– reference: 18339710 - Endocrinology. 2008 Jun;149(6):3037-45
– reference: 17016550 - J Clin Invest. 2006 Oct;116(10):2571-9
– reference: 11898402 - Methods Enzymol. 2002;347:125-67
– reference: 4380584 - Med Pharmacol Exp Int J Exp Med. 1966;15(1):17-23
– reference: 17912534 - J Comp Physiol B. 2008 Feb;178(2):167-77
– reference: 18420141 - Chem Biol. 2008 Apr;15(4):343-53
– reference: 5351077 - Pharmacology. 1969;2(5):281-7
– reference: 11427693 - Physiol Rev. 2001 Jul;81(3):1097-142
– reference: 19105176 - Chembiochem. 2009 Jan 26;10(2):361-5
– reference: 17530732 - ACS Chem Biol. 2007 Jun 15;2(6):390-8
– reference: 14887111 - C R Seances Soc Biol Fil. 1951 Jun;145(11-12):797-800
– reference: 4152982 - J Theor Biol. 1974 Jul;46(1):255-70
– reference: 6319258 - Horm Metab Res. 1983 Dec;15(12):602-6
– reference: 18823891 - J Chromatogr A. 2008 Nov 7;1210(1):55-9
– reference: 17284482 - FASEB J. 2007 May;21(7):1597-608
– reference: 17992256 - J Clin Invest. 2007 Dec;117(12):4034-43
– reference: 17204552 - Endocrinology. 2007 Apr;148(4):1921-7
– reference: 17690312 - Stroke. 2007 Sep;38(9):2569-76
– reference: 4715216 - Eur J Pharmacol. 1973 May;22(2):141-9
– reference: 18752950 - Bioorg Med Chem Lett. 2008 Nov 15;18(22):5920-2
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Snippet 3-Iodothyronamine (T(1)AM) is an endogenous compound with chemical features that are similar to thyroid hormone. T(1)AM has a carbon skeleton identical to that...
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SubjectTerms Animals
Endocrine System - physiology
Humans
Models, Biological
Thyroid Gland - physiology
Thyronines - physiology
Title Minireview: 3-Iodothyronamine (T1AM): a new player on the thyroid endocrine team?
URI https://www.ncbi.nlm.nih.gov/pubmed/19116337
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