Minireview: 3-Iodothyronamine (T1AM): a new player on the thyroid endocrine team?

3-Iodothyronamine (T(1)AM) is an endogenous compound with chemical features that are similar to thyroid hormone. T(1)AM has a carbon skeleton identical to that of T(4) and contains a single carbon-iodine bond. Theoretically, T(1)AM could be produced from T(4) by enzymatic decarboxylation and deiodin...

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Bibliographic Details
Published inEndocrinology (Philadelphia) Vol. 150; no. 3; p. 1108
Main Author Scanlan, Thomas S
Format Journal Article
LanguageEnglish
Published United States 01.03.2009
Subjects
Animals
Endocrine System - physiology
Humans
Models, Biological
Thyroid Gland - physiology
Thyronines - physiology
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ISSN1945-7170
1945-7170
DOI10.1210/en.2008-1596

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Summary:3-Iodothyronamine (T(1)AM) is an endogenous compound with chemical features that are similar to thyroid hormone. T(1)AM has a carbon skeleton identical to that of T(4) and contains a single carbon-iodine bond. Theoretically, T(1)AM could be produced from T(4) by enzymatic decarboxylation and deiodination. Recent studies show that T(1)AM and higher iodinated thyronamines are subject to similar metabolic processing as iodothyronines such as T(4), suggesting a biological linkage between iodothyronines and iodothyronamines. In addition, single doses of T(1)AM administered to rodents induce a hypometabolic state that in certain ways resembles hibernation and is opposite to the effects of excess T(4). This review will discuss the latest developments on this recently discovered thyroid hormone derivative.
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ISSN:1945-7170
1945-7170
DOI:10.1210/en.2008-1596