Serotonin syndrome caused by olanzapine and clomipramine

We describe a case of severe serotonin syndrome. The patient was simultaneously taking the atypical antidepressant olanzapine and a tricyclical antidepressant, clomipramine. Symptoms included altered mental state resulting in coma, myoclonus, hyperreflexia, diaphoresis, diarrhoea, disorientation and...

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Bibliographic Details
Published inMinerva anestesiologica Vol. 74; no. 1-2; p. 41
Main Authors Verre, M, Bossio, F, Mammone, A, Piccirillo, M, Tancioni, F, Tortorella, V, Varano, M
Format Journal Article
LanguageEnglish
Published Italy 01.01.2008
Subjects
Antidepressive Agents, Tricyclic - adverse effects
Antipsychotic Agents - adverse effects
Benzodiazepines - adverse effects
Clomipramine - adverse effects
Humans
Male
Middle Aged
Serotonin Syndrome - chemically induced
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Summary:We describe a case of severe serotonin syndrome. The patient was simultaneously taking the atypical antidepressant olanzapine and a tricyclical antidepressant, clomipramine. Symptoms included altered mental state resulting in coma, myoclonus, hyperreflexia, diaphoresis, diarrhoea, disorientation and fever. After suspension of antidepressant drugs, intensive symptomatic treatment and administration of biperiden and cyproheptadine, the patient's condition improved.
ISSN:1827-1596