Evaluation of the efficacy provided by a Recombinant Canarypox-Vectored Equine West Nile Virus vaccine against an experimental West Nile Virus intrathecal challenge in horses

Efficacy of the Recombitek Equine West Nile Virus (WNV) vaccine was evaluated against a WNV intrathecal challenge model that results in WNV-induced clinical disease. Ten vaccinated (twice at days 0 and 35) and 10 control horses were challenged 2 weeks after administration of the second vaccine with...

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Published inVeterinary therapeutics Vol. 7; no. 3; p. 249
Main Authors Siger, Leonardo, Bowen, Richard, Karaca, Kemal, Murray, Michael, Jagannatha, Shyla, Echols, Brandy, Nordgren, Robert, Minke, Jules M
Format Journal Article
LanguageEnglish
Published United States 2006
Subjects
Animals
Antibodies, Viral - biosynthesis
Antibodies, Viral - blood
Canarypox virus - immunology
Culicidae - virology
Female
Horse Diseases - prevention & control
Horses
Male
Random Allocation
Treatment Outcome
Viremia - veterinary
West Nile Fever - prevention & control
West Nile Fever - veterinary
West Nile virus - immunology
West Nile virus - pathogenicity
West Nile Virus Vaccines - immunology
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Summary:Efficacy of the Recombitek Equine West Nile Virus (WNV) vaccine was evaluated against a WNV intrathecal challenge model that results in WNV-induced clinical disease. Ten vaccinated (twice at days 0 and 35) and 10 control horses were challenged 2 weeks after administration of the second vaccine with a virulent WNV by intrathecal administration. After the challenge, eight of 10 controls developed clinical signs of encephalomyelitis whereas one vaccinate exhibited muscle fasciculation only once. Nine controls and one vaccinate developed a fever. Histopathology revealed mild to moderate nonsuppurative encephalitis in eight controls and one vaccinate. None of the vaccinates and all of the controls developed WNV viremia after challenge. All vaccinated horses developed antibodies to WNV after vaccination. These and results of previous studies demonstrate efficacy of the Recombitek WNV vaccine against WNV-induced clinical disease and natural challenge with WNV-infected mosquitoes.
ISSN:1528-3593