Subarachnoid hemorrhage and cerebral vasospasm - literature review

• Published in: Journal of medicine and life Vol. 6; no. 2; pp. 120 - 125
• Main Authors: Ciurea, A V, Palade, C, Voinescu, D, Nica, D A
• Format: Journal Article
• Language: English
• Published: Romania Carol Daila University Foundation 15.06.2013; Carol Davila University Press
• Subjects: Apoptosis - physiology; Humans; Hypoxia-Inducible Factor 1 - metabolism; Nitrous Oxide - metabolism; Review; Subarachnoid Hemorrhage - etiology; Subarachnoid Hemorrhage - metabolism; Subarachnoid Hemorrhage - physiopathology; Vasospasm, Intracranial - etiology; Vasospasm, Intracranial - metabolism; Vasospasm, Intracranial - physiopathology; Hypoxia induced factor-1; Nitrous oxide; Early brain injury; Apoptosis
• ISSN: 1844-122X; 1844-3117

Subarachnoid hemorrhage represents a serious disease with high mortality and morbidity. Two important areas are becoming the central research interest of subarachnoid hemorrhage: cerebral vasospasm and early brain injury. The authors have reviewed the major contributions in experimental subarachnoid hemorrhage documented in the medical literature in the past 5 years. Treatments interfering with nitric oxide - or endothelin-pathways continue to show antispasmotic effects in experimental models of subarachnoid hemorrhage. Inflammation and oxidative stress play a vital role in the pathophysiology of cerebral vasospasm. Apoptosis, a relevant cause of early brain injury after subarachnoid hemorrhage, also underline the etiology of cerebral vasospasm. Future research studies will continue to elucidate the pathophysiological pathways and treatment modalities targeting cerebral vasospasm and early brain injury, enabling an improvement in outcome for patients with subarachnoid hemorrhage.