Application of ghrelin to gastrointestinal diseases

This review outlines recent findings related to the therapeutic potential of ghrelin agonists or antagonists for the treatment of gastrointestinal (GI) motility disorders and the regulation of the hypothalamic control of feeding. The ability of ghrelin to promote GI motility in patients with postope...

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Bibliographic Details
Published inCurrent opinion in investigational drugs (London, England : 2000) Vol. 9; no. 10; p. 1103
Main Authors Venkova, Kalina, Greenwood-Van Meerveld, Beverley
Format Journal Article
LanguageEnglish
Published England 01.10.2008
Subjects
Aging - physiology
Animals
Antineoplastic Agents - adverse effects
Appetite - physiology
Dyspepsia - chemically induced
Dyspepsia - drug therapy
Eating - physiology
Gastrointestinal Diseases - drug therapy
Gastrointestinal Motility - physiology
Gastroparesis - drug therapy
Ghrelin - physiology
Ghrelin - therapeutic use
Humans
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Summary:This review outlines recent findings related to the therapeutic potential of ghrelin agonists or antagonists for the treatment of gastrointestinal (GI) motility disorders and the regulation of the hypothalamic control of feeding. The ability of ghrelin to promote GI motility in patients with postoperative ileus or gastroparesis, and to restore the normal feeding pattern and energy balance in the elderly and in cancer patients with impaired appetite are highlighted. A critical analysis of the possible mechanism of action and the potential benefits of using synthetic ghrelin agonists is based on data from preclinical research and recent clinical studies.
ISSN:1472-4472