Warfarin-induced skin necrosis and heparin-induced thrombocytopenia following mitral valve replacement for marantic endocarditis

Hemostatic physiology involves a complex interlinking of blood and endothelial factors. Its pharmacological manipulation invariably impacts at multiple molecular sites. Herein is reported an unusual case of coexistent warfarin-induced skin necrosis and heparin-induced thrombocytopenia following mitr...

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Bibliographic Details
Published inThe Journal of heart valve disease Vol. 15; no. 5; p. 716
Main Authors White, Craig A, Chung, Darryl A, Thomas, Martyn, Marrinan, Michael T
Format Journal Article
LanguageEnglish
Published England 01.09.2006
Subjects
Adenocarcinoma - complications
Adenocarcinoma - pathology
Anticoagulants - adverse effects
Bronchial Neoplasms - complications
Bronchial Neoplasms - pathology
Endocarditis - surgery
Fatal Outcome
Heart Valve Diseases - surgery
Heart Valve Prosthesis Implantation
Heparin - adverse effects
Humans
Intracranial Embolism - drug therapy
Intracranial Embolism - etiology
Male
Middle Aged
Mitral Valve - surgery
Necrosis - chemically induced
Postoperative Complications - etiology
Skin - drug effects
Skin - pathology
Thrombocytopenia - chemically induced
Warfarin - adverse effects
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Summary:Hemostatic physiology involves a complex interlinking of blood and endothelial factors. Its pharmacological manipulation invariably impacts at multiple molecular sites. Herein is reported an unusual case of coexistent warfarin-induced skin necrosis and heparin-induced thrombocytopenia following mitral valve replacement for thromboembolic phenomena associated with marantic endocarditis and bronchial adenocarcinoma. Thrombophilia in the face of endocarditis should be treated with a suspicion of underlying cancer.
ISSN:0966-8519