Activity of lipid peroxidation and functional state of the myocardium in remodeling of rat heart after experimental myocardial infarction

• Published in: Kardiologiia Vol. 47; no. 6; p. 41
• Main Authors: Rebrova, T Iu, Kondrat'eva, D S, Afanas'ev, S A, Barzakh, E I
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2007
• Subjects: Animals; Disease Models, Animal; Lipid Peroxidation - physiology; Malondialdehyde - metabolism; Myocardial Contraction - physiology; Myocardial Infarction - metabolism; Myocardial Infarction - pathology; Myocardial Infarction - physiopathology; Myocardium - metabolism; Myocardium - pathology; Myocytes, Cardiac - metabolism; Myocytes, Cardiac - pathology; Rats; Rats, Wistar; Sarcoplasmic Reticulum - metabolism; Sarcoplasmic Reticulum - pathology; Severity of Illness Index; Ventricular Remodeling - physiology
• ISSN: 0022-9040

It was shown in experiments on Wistar rats that the processes of postinfarction remodeling of the heart in animals that survived myocardial infarction were characterized by lowering of excitability of cardiac muscle, impairment of ability of sarcoplasmic reticulum to accumulate calcium ions. High level of content of lipid peroxidation products both in blood serum and myocardial tissue, and lowering of activity of antioxidant enzymes were also noted. A conclusion was made that high level of lipid peroxidation, lowering of defense properties of endogenous antioxidants and impairment of myocardial contractile function induced by myocardial infarction were sustained minimally for subsequent 45 days. This could serve as a factor, capable to significantly affect the process of postinfarction remodeling and development of heart failure.