Recent advances in estrogen receptor modulators

Modulation of estrogen action is an effective treatment for alleviating the symptoms associated with menopause, and also provides an alternative to ablative surgery for the treatment of breast cancer. The side effects associated with the currently used estrogen receptor-modulating drugs have resulte...

Full description

Saved in:
Bibliographic Details
Published inCurrent opinion in drug discovery & development Vol. 8; no. 4; p. 437
Main Authors Henke, Brad R, Heyer, Dennis
Format Journal Article
LanguageEnglish
Published England 01.07.2005
Subjects
Animals
Humans
Ligands
Receptors, Estrogen - agonists
Receptors, Estrogen - antagonists & inhibitors
Receptors, Estrogen - drug effects
Selective Estrogen Receptor Modulators - pharmacology
Selective Estrogen Receptor Modulators - therapeutic use
Online AccessGet more information

Cover

More Information
Summary:Modulation of estrogen action is an effective treatment for alleviating the symptoms associated with menopause, and also provides an alternative to ablative surgery for the treatment of breast cancer. The side effects associated with the currently used estrogen receptor-modulating drugs have resulted in the pursuit of agents with an improved therapeutic profile. Recent advances in understanding the molecular determinants of estrogen receptor signaling have contributed to the continued discovery and development of novel chemical compounds designed to exploit this knowledge. This review focuses on the recent clinical and preclinical development of novel classes of ligands that modulate the two estrogen receptor subtypes.
ISSN:1367-6733