Simultaneous pancreas-kidney transplant: a single-center long-term outcome

In patients with type 1 diabetes mellitus and end-stage renal disease, simultaneous pancreas-kidney transplantation is associated with increased survival when compared with solitary deceased kidney transplant or dialysis. We consider that the analysis of our long-term program (based in a single cent...

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Published inJournal of nephrology Vol. 20; no. 2; p. 173
Main Authors Aguera, María Luisa, Navarro, María Dolores, Pérez-Calderón, Rodrigo, Rodríguez-Benot, Alberto, Ojeda, Raquel, Valle, Casimiro, Padillo, Javier, Requena, María José, Rodríguez, Mariano, del Castillo, Domingo, Aljama, Pedro
Format Journal Article
LanguageEnglish
Published Italy 01.03.2007
Subjects
Adult
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 1 - surgery
Female
Graft Survival
Humans
Kaplan-Meier Estimate
Kidney Failure, Chronic - complications
Kidney Failure, Chronic - surgery
Kidney Transplantation - mortality
Longitudinal Studies
Male
Middle Aged
Pancreas Transplantation - mortality
Risk Factors
Treatment Outcome
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Summary:In patients with type 1 diabetes mellitus and end-stage renal disease, simultaneous pancreas-kidney transplantation is associated with increased survival when compared with solitary deceased kidney transplant or dialysis. We consider that the analysis of our long-term program (based in a single center) of simultaneous pancreas-kidney transplantation would provide valuable information for this therapeutic approach regarding patient and organ survival. The outcome of 57 consecutive pancreas-kidney transplants patients was analyzed. The analysis included characteristics of the donor and recipient and survival rates of patients and both grafts. We also analyzed age and modality of renal replacement treatment as possible mortality risk factors. Ten-year patient, kidney and pancreas graft survival rates were 75.8%, 57.2% and 42.7%, respectively. Censoring for patient death, the results for 10-year kidney and pancreas survival were 78.5% and 58%, respectively. Our results add evidence to support the notion that the double and simultaneous pancreas-kidney transplantation is in fact the treatment of choice in selected patients with end-stage renal failure due to type 1 diabetes mellitus.
ISSN:1121-8428