Functional state of endothelium and oxidant activity of leucocytes in patients with ischemic heart disease after coronary bypass surgery

Relationship between disorders of endothelial function, proinflammatory activity of leucocytes and effects of therapy with simvastatin or its combination with ezetimibe was studied in 72 patients with ischemic heart disease subjected to coronary artery bypass grafting (CABG). Vascular endothelial fu...

Full description

Saved in:
Bibliographic Details
Published inKardiologiia Vol. 47; no. 4; p. 32
Main Authors Panov, A V, Abesadze, I T, Korzhenevskaia, K V, Nil'k, R Ia, Kozulin, V Iu, Gordeev, M L, Shliakhto, E V
Format Journal Article
LanguageRussian
Published Russia (Federation) 2007
Subjects
Adult
Anticholesteremic Agents - therapeutic use
Azetidines - therapeutic use
Case-Control Studies
Coronary Angiography
Coronary Artery Bypass
Drug Therapy, Combination
Endothelium, Vascular - metabolism
Endothelium, Vascular - physiopathology
Ezetimibe
Female
Humans
Leukocytes - metabolism
Luminescent Measurements
Male
Microscopy - methods
Middle Aged
Myocardial Ischemia - blood
Myocardial Ischemia - drug therapy
Myocardial Ischemia - metabolism
Myocardial Ischemia - physiopathology
Myocardial Ischemia - surgery
Oxidation-Reduction
Severity of Illness Index
Simvastatin - therapeutic use
Treatment Outcome
Online AccessGet more information

Cover

More Information
Summary:Relationship between disorders of endothelial function, proinflammatory activity of leucocytes and effects of therapy with simvastatin or its combination with ezetimibe was studied in 72 patients with ischemic heart disease subjected to coronary artery bypass grafting (CABG). Vascular endothelial function was assessed by ultrasound detection of brachial artery response to its compression, oxidant activity of leucocytes - by chemiluminescent microscopy, severity of coronary artery atherosclerosis - by invasive coronary angiography. Twenty two healthy individuals comprised control group. Endothelial function, activity of leucocytes, and lipid levels were evaluated before and in 12 months after CABG. Patients with multivessel involvement revealed more complex disorders of endothelial function and higher levels of leucocytes activity compared to patients with single-vessel disease. CABG resulted in disappearance of anginal attacks and negative stress echo test during 1-year observation in 80.6% of patients. Patients with recurrent angina after CABG had more severe endothelial and leucocytes disorders. Combined lipid lowering therapy (simvastatin plus ezetimibe) compared to simvastatin alone demonstrated higher efficacy in terms of achievement of target lipid levels, improvement of endothelial function and leucocytes disorders.
ISSN:0022-9040