A complex translocation t(5;9;22) in Philadelphia cells involving the short arm of chromosome 5 in a case of chronic myelogenous leukemia

Chronic myelogenous leukemia (CML) is genetically characterized by the reciprocal translocation of chromosome 9 and 22, t(9;22)(q34;q11) which results in the fusion of BCR/ABL gene observed on the derivative chromosome 22 called Philadelphia (Ph') chromosome. About 5-8% of Philadelphia positive...

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Bibliographic Details
Published inJournal of experimental & clinical cancer research Vol. 26; no. 3; p. 411
Main Authors Al-Achkar, W, Wafa, A, Nweder, M S
Format Journal Article
LanguageEnglish
Published England 01.09.2007
Subjects
Child
Chromosomes, Human, Pair 5
Humans
In Situ Hybridization, Fluorescence
Karyotyping
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics
Male
Philadelphia Chromosome
Proto-Oncogenes
Translocation, Genetic
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Summary:Chronic myelogenous leukemia (CML) is genetically characterized by the reciprocal translocation of chromosome 9 and 22, t(9;22)(q34;q11) which results in the fusion of BCR/ABL gene observed on the derivative chromosome 22 called Philadelphia (Ph') chromosome. About 5-8% of Philadelphia positive patients with CML show various complex translocations involving one or more other chromosomes, in addition to chromosome 9 and 22. In our report we discuss one case with CML, his cytogenetic study revealed a complex translocation t(5;9;22)(p15.1; q34; q11.2), del 5p15.1-->pter, translocation BCR(22q11.2-->qter) to der(5), positive Ph-chromosome and positive t(BCR\ABL). Further confirmation of complex translocation was done by FISH study using the LSI BCR/ABL dual color dual fusion (DF) translocation probe, chromosome 5 and 22 whole paint probes.
ISSN:0392-9078