Metal-organic framework combined with CaO2 nanoparticles for enhanced and targeted photodynamic therapy

• Published in: Nanoscale advances Vol. 3; no. 23; pp. 6669 - 6677
• Main Authors: Sun, Xinran, Chen, Kaixiu, Liu, Yingyan, Zhang, Guoda, Shi, Min, Shi, Pengfei, Zhang, Shusheng
• Format: Journal Article
• Language: English
• Published: RSC 24.11.2021
• Subjects: Chemistry
• ISSN: 2516-0230
• DOI: 10.1039/d1na00610j

Photodynamic therapy (PDT) has been rapidly developed as an effective therapeutic approach in clinical settings. However, hypoxia seriously limits the effectiveness of PDT. Here, we report a porphyrin-based metal–organic framework combined with hyaluronate-modified CaO 2 nanoparticles (PCN-224-CaO 2 -HA) to target and enhance PDT efficacy. CaO 2 reacts with H 2 O or weak acid to produce O 2 , overcoming the hypoxia problem. Hyaluronate protects CaO 2 and specifically targets the CD44 receptor, which is highly expressed on tumor cell membranes, performing targeted therapy. After PDT treatment in vitro , the survival rates of 4T1 and MCF-7 tumor cells were 14.58% and 22.45%, respectively. The fluorescence imaging showed that PCN-224-CaO 2 -HA effectively aggregated in the tumor after 12 h of its intravenous injection into tumor-bearing mice. PCN-224-CaO 2 -HA exhibited efficacious tumor growth inhibition via enhanced PDT. Overall, this nanosystem providing in situ oxygen production was successfully used for targeted PDT with a significantly enhanced therapeutic efficacy in vitro and in vivo . A self-supplying O 2 nanosystem based on MOF combined with hyaluronate-modified CaO 2 (PCN-224-CaO 2 -HA) was constructed. This nanosystem can be used for targeted and enhanced photodynamic therapy in vitro and in vivo .