Malignant germ cell tumors of the ovary: a review of 41 cases and risk factors for recurrence

To review the outcome of treatment in patients with malignant ovarian germ cell tumors and to define the risk factors for recurrence. Forty-one patients with malignant ovarian germ cell tumors were reviewed retrospectively. Survival time and survival rate were obtained. Risk factors such as stage, h...

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Published inEuropean journal of gynaecological oncology Vol. 29; no. 6; p. 635
Main Authors Topuz, S, Iyibozkurt, A Cem, Akhan, S Engin, Keskin, N, Yavuz, E, Salihoglu, Y, Bengisu, E, Berkman, S
Format Journal Article
LanguageEnglish
Published Italy 2008
Subjects
Adolescent
Adult
Aged
Child
Cohort Studies
Dysgerminoma - pathology
Dysgerminoma - surgery
Female
Humans
Middle Aged
Neoplasm Recurrence, Local
Neoplasm Staging
Neoplasms, Germ Cell and Embryonal - pathology
Neoplasms, Germ Cell and Embryonal - surgery
Ovarian Neoplasms - pathology
Ovarian Neoplasms - surgery
Retrospective Studies
Risk Factors
Young Adult
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Summary:To review the outcome of treatment in patients with malignant ovarian germ cell tumors and to define the risk factors for recurrence. Forty-one patients with malignant ovarian germ cell tumors were reviewed retrospectively. Survival time and survival rate were obtained. Risk factors such as stage, histological type, and type of operation were evaluated for reccurrence. Twenty-three (56%) had dysgerminomas, eight (19.5%) had mixed germ cell tumors, three (7.3%) had yolk sac tumors, three (7.3%) had immature teratomas, two (4.8%) had squamous cell carcinoma arising from a mature teratoma, one (2.4%) had embryonal carcinoma and one choriocarcinoma. Most of the cases (73%) were in Stage I. Twenty-nine patients (70.7%) underwent conservative surgery and 12 patients (29.3%) had at least bilateral salpingo-oophorectomy. Thirty patients were operated on optimally with surgical staging and 11 suboptimally. Seven patients (17%) had recurrence after remission. The overall survival time was 187 +/- 8.43 months for all cases, 195 +/- 8.49 for dysgerminoma and 161 +/- 10.96 for non-dysgerminoma cases with a median follow-up time of 98.52 (8-204) months. Non-dysgerminoma histologic type, being operated on suboptimally and radically, and advanced tumor stage have been found to be risk factors for recurrence. Regardless of histologic types and stages the prognosis of germ cell tumors are satisfactory with current therapeutic strategies.
ISSN:0392-2936