Effect of therapy with atorvastatin on parameters of postprandial lipemia and factors of inflammation in patients with ischemic heart disease

Reaction of parameters of lipid transport system to standard fat load (J.Patsch method), C-reactive protein (CRP) and fibrinogen levels were studied in 30 patients with ischemic heart disease before and after 3 months of therapy with atorvastatin (10 mg/day). Atorvastatin therapy resulted in 25, 34,...

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Published inKardiologiia Vol. 47; no. 2; p. 4
Main Authors Samoĭlenko, E Iu, Naumov, V G, Tvorogova, M G, Ezhov, M V, Sergienko, I V, Kukharchuk, V V
Format Journal Article
LanguageRussian
Published Russia (Federation) 2007
Subjects
Adult
Anticholesteremic Agents - pharmacology
Anticholesteremic Agents - therapeutic use
Atorvastatin Calcium
C-Reactive Protein - analysis
Female
Fibrinogen - analysis
Heptanoic Acids - pharmacology
Heptanoic Acids - therapeutic use
Humans
Hyperlipidemias - complications
Hyperlipidemias - drug therapy
Inflammation - complications
Inflammation - drug therapy
Lipids - blood
Male
Myocardial Ischemia - complications
Postprandial Period - drug effects
Pyrroles - pharmacology
Pyrroles - therapeutic use
Treatment Outcome
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Summary:Reaction of parameters of lipid transport system to standard fat load (J.Patsch method), C-reactive protein (CRP) and fibrinogen levels were studied in 30 patients with ischemic heart disease before and after 3 months of therapy with atorvastatin (10 mg/day). Atorvastatin therapy resulted in 25, 34, 17 and 16% lowering of concentrations of total cholesterol (CH), low density lipoprotein CH, triglycerides (TG), and apolipoprotein (apo) B, respectively, 6 and 9% elevation of high density lipoprotein CH and apo A-1 levels, respectively. Moreover atorvastatin improved although not completely normalized parameters of postprandial lipemia: significant lowering of baseline (-17%), 3 (-19%) and 6 hour (-14%) post load TG levels was noted. However relative TG elevation from baseline level to 3 and 6 hours after fat load did not change (+100 and 148% before, +95 and 156% after treatment, respectively). Changes of CRP (-22%) and fibrinogen (-8%) were not significant (p>0.05).
ISSN:0022-9040