The use of lucetam for improvement of cognitive functions in chronic cerebrovascular insufficiency (clinical and encephalographic study)

• Published in: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova Vol. 107; no. 4; p. 44
• Main Authors: Bugrova, S G, Novikov, A E
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2007
• Subjects: Adult; Cerebrovascular Disorders - complications; Cerebrovascular Disorders - drug therapy; Cerebrovascular Disorders - psychology; Chronic Disease; Cognition - drug effects; Cognition - physiology; Cognition Disorders - drug therapy; Cognition Disorders - etiology; Cognition Disorders - physiopathology; Disease Progression; Dose-Response Relationship, Drug; Electroencephalography - drug effects; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neuroprotective Agents - administration & dosage; Neuroprotective Agents - therapeutic use; Piracetam - administration & dosage; Piracetam - therapeutic use; Retrospective Studies; Treatment Outcome
• ISSN: 1997-7298

One hundred and ninety-three patients, aged 35-60 years, with chronic cerebrovascular insufficiency of I and II stage have been studied. It has been shown that memory and attention disturbances at stage I are of pseudomnemonic character. At stage II, the syndrome of mild cognitive impairment is formed first with the following formation of the moderate one. After the treatment with lucetam, the overall improvement as measured by neurophysiological testing was observed in 64% of patients, the memory improvement - in 18%, the attention improvement - in 10% and no positive effect was found in 8%. The significant improvement of cognitive functioning was correlated with positive changes of brain neurodynamics in the EEG study.