Sarcopenia: the role of apoptosis and modulation by caloric restriction

The mechanisms of sarcopenia have been slowly unraveled and likely involve activation of apoptosis. It is hypothesized that caloric restriction may, in part, attenuate sarcopenia by affecting apoptotic signaling. The signaling pathways responsible for the execution of apoptosis in aging muscle and t...

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Bibliographic Details
Published inExercise and sport sciences reviews Vol. 36; no. 1; p. 19
Main Authors Dirks Naylor, Amie J, Leeuwenburgh, Christiaan
Format Journal Article
LanguageEnglish
Published United States 01.01.2008
Subjects
Aged
Aging - physiology
Apoptosis - physiology
Caloric Restriction
Female
Humans
Male
Muscular Atrophy - etiology
United States
United States
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Summary:The mechanisms of sarcopenia have been slowly unraveled and likely involve activation of apoptosis. It is hypothesized that caloric restriction may, in part, attenuate sarcopenia by affecting apoptotic signaling. The signaling pathways responsible for the execution of apoptosis in aging muscle and the modulation of these pathways by caloric restriction are discussed.
ISSN:0091-6331
DOI:10.1097/jes.0b013e31815ddd9d