Level of hormones of pituitary-gonadal axis, penile blood flow and sexual function in men with arterial hypertension during monotherapy with bisoprolol and nebivolol

Measurement of levels of hormones of the pituitary-gonadal system, dopplerography of penile arteries and questioning after Vasiltchenko were carried out in 30 men (age 35-55 years) with I-II degree arterial hypertension who received monotherapy with bisoprolol and nebivolol for 2 months. Treatment w...

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Bibliographic Details
Published inKardiologiia Vol. 47; no. 6; p. 50
Main Authors Nurmamedova, G S, Gumbatov, N B, Mustafaev, I I
Format Journal Article
LanguageRussian
Published Russia (Federation) 2007
Subjects
Adrenergic beta-Antagonists - therapeutic use
Adult
Benzopyrans - therapeutic use
Bisoprolol - therapeutic use
Blood Flow Velocity - drug effects
Blood Flow Velocity - physiology
Blood Pressure - drug effects
Blood Pressure - physiology
Drug Therapy, Combination
Ethanolamines - therapeutic use
Follow-Up Studies
Gonadal Hormones - blood
Humans
Hypertension - blood
Hypertension - drug therapy
Hypertension - physiopathology
Immunoenzyme Techniques
Male
Middle Aged
Nebivolol
Nitric Oxide
Penis - blood supply
Penis - diagnostic imaging
Sexuality - drug effects
Sexuality - physiology
Treatment Outcome
Ultrasonography, Doppler
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Summary:Measurement of levels of hormones of the pituitary-gonadal system, dopplerography of penile arteries and questioning after Vasiltchenko were carried out in 30 men (age 35-55 years) with I-II degree arterial hypertension who received monotherapy with bisoprolol and nebivolol for 2 months. Treatment with both superselective beta-adrenoblockers was associated with significant lowering of systolic and diastolic blood pressure and heart rate. Antihypertensive effect of bisoprolol was significantly more pronounced than that of nebivolol. Bisoprolol and nebivolol significantly increased concentration of testosterone (by 82 and 85%, respectively) and prolactin (by 77 and 83%, respectively), lowered levels of estradiol and follicle-stimulating hormone, improved vascular blood flow in penile arteries, and did not worsen sexual function.
ISSN:0022-9040