Oxidative stress in the blood of patients with active localized vitiligo

Vitiligo is an acquired skin disease characterized by white areas on the skin. The pathogenesis of the disease is still unclear. Some findings show that oxidative stress could be an important phenomenon in the pathophysiology of vitiligo. We evaluated 16 consecutive localized vitiligo patients and 1...

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Published inActa dermatovenerologica Alpina, Panonica, et Adriatica Vol. 17; no. 1; pp. 12 - 16
Main Authors Arican, Ozer, Kurutas, Ergül Belge
Format Journal Article
LanguageEnglish
Published Slovenia 01.03.2008
Subjects
Adolescent
Adult
Catalase - blood
Child
Child, Preschool
Erythrocytes - enzymology
Female
Glucosephosphate Dehydrogenase - blood
Humans
Male
Malondialdehyde - blood
Middle Aged
Oxidative Stress
Superoxide Dismutase - blood
Vitiligo - blood
Vitiligo - etiology
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Summary:Vitiligo is an acquired skin disease characterized by white areas on the skin. The pathogenesis of the disease is still unclear. Some findings show that oxidative stress could be an important phenomenon in the pathophysiology of vitiligo. We evaluated 16 consecutive localized vitiligo patients and 16 healthy controls of a similar age and sex distribution. We measured their indicators of oxidative stress such as catalase (CAT), superoxide dismutase (SOD), glucose 6-phosphate dehydrogenase (G6PD) in erythrocytes, and plasma malondialdehyde (MDA) by spectrophotometry. SOD activities and MDA levels of patients were significantly higher than controls (p < 0.001). CAT and G6PD activities of patients were significantly lower than controls (p < 0.05 and p < 0.001, respectively). Our results confirmed that oxidative stress may play an important role in the pathogenesis of vitiligo. Melanocyte damage in vitiligo might be linked to generalized oxidative stress. This study is the first report on some antioxidant parameters of localized-type vitiligo patients.
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ISSN:1318-4458