Transient hyperphosphatasemia in an infant with bronchiolitis and pneumonia

We present a case of benign transient hyperphosphatasemia in a 4-month-old infant with acute bronchiolitis and pneumonia. During hospitalization the infant had an increased catalytic activity of alkaline phosphatase (ALP): day 2, 5074 U/L; day 3, 5622-U/L; and day 8, 3129 U/L. The x-ray, leukocytosi...

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Bibliographic Details
Published inEuropean journal of medical research Vol. 13; no. 11; p. 536
Main Authors Dodig, Slavica, Demirovic, J, Jelcic, Z, Richter, D, Cepelak, I, Zrinski Topic, R, Petrinovic, R
Format Journal Article
LanguageEnglish
Published England 24.11.2008
Subjects
Acute Disease
Alkaline Phosphatase - blood
Bronchiolitis - complications
Female
Humans
Hyperphosphatemia - diagnosis
Hyperphosphatemia - etiology
Infant
Isoenzymes - blood
Pneumonia - complications
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Summary:We present a case of benign transient hyperphosphatasemia in a 4-month-old infant with acute bronchiolitis and pneumonia. During hospitalization the infant had an increased catalytic activity of alkaline phosphatase (ALP): day 2, 5074 U/L; day 3, 5622-U/L; and day 8, 3129 U/L. The x-ray, leukocytosis, and C-reactive protein findings pointed to bacterial etiology of the respiratory disorder. Electrophoretic separation revealed an atypical isoenzyme profile: fast anodal, near-cathodal and bone fractions. ALP levels normalized within 54 days, and control electrophoresis indicated normal liver, placental/placental-like, intestinal and bone isoenzymes. The appearance of atypical fast anodal and near-cathodal fractions of ALP in this infant during the course of acute lower respiratory tract infection and rapid return to the reference intervals pointed to benign transient hyperphosphatasemia.
ISSN:0949-2321