Combined impact of matrix metalloproteinase-3 and paraoxonase 1 55/192 gene variants on coronary artery disease in Turkish patients

• Published in: Medical science monitor Vol. 14; no. 10; pp. CR536 - CR542
• Main Authors: Ozkök, Elif, Aydin, Makbule, Babalik, Erhan, Ozbek, Zeynep, Ince, Nurhan, Kara, Ihsan
• Format: Journal Article
• Language: English
• Published: United States 01.10.2008
• Subjects: Adult; Aged; Alleles; Aryldialkylphosphatase - genetics; Coronary Artery Disease - genetics; Coronary Artery Disease - pathology; Diabetes Mellitus - genetics; Female; Genetic Predisposition to Disease; Genotype; Humans; Hyperlipidemias - genetics; Hypertension - genetics; Male; Matrix Metalloproteinase 3 - genetics; Middle Aged; Myocardial Infarction - genetics; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Turkey; Turkey
• ISSN: 1643-3750

We investigated the association of matrix metalloproteinase-3 (MMP-3) and paraoxonase 1 (PON1) 55/192 polymorphisms with coronary artery disease (CAD) and the number of diseased vessels in patients with CAD. One hundred thirty-nine CAD patients and 119 healthy control subjects were included in the study. Genotypes for PON1 55/192 and MMP-3 5A/6A polymorphisms were determined by restriction fragment length polymorphism. Although distributions of the RR genotype of PON1 192 and the 5A5A genotype of MMP-3 were more frequent in patients, frequencies of the QQ genotype of PON1 192, the MM genotype of PON1 55, and the 6A6A genotype of MMP-3 were significantly lower in patients compared with healthy control subjects. The combined genotypes of RR/LL and/or 5A5A are increased the risk of CAD when compared with subjects who possess neither the MMP-3 5A5A nor the PON1 RR/LL genotype. While the MMP-3 5A/6A genetic variants were not associated with the number of diseased vessels, PON1 55/192 variants were associated with the number of diseased vessels. The combined PON1 55/192 and MMP-3 5A/6A genetic variants are associated with CAD; PON1 seems to be connected with the number of diseased vessels, and hypertension and hyperlipidemia are related with PON1 192 and MMP-3 in CAD patients.