Acute lead intoxication in a pregnant mare

Lead (Pb) intoxication in horses is usually a chronic phenomenon with clinical signs associated with central nervous dysfunction. This report gives details of a case of acute Pb intoxication in a 9-year-old American Saddlebred mare with severe, progressive and ultimately fatal neurological deteriora...

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Bibliographic Details
Published inJournal of the South African Veterinary Association Vol. 79; no. 1; p. 50
Main Authors Kruger, K, Saulez, M N, Neser, J A, Solberg, K
Format Journal Article
LanguageEnglish
Published South Africa 01.03.2008
Subjects
Acute Disease
Animals
Brain - drug effects
Brain - metabolism
Fatal Outcome
Female
Gastric Mucosa - metabolism
Horse Diseases - diagnosis
Horses
Kidney - drug effects
Kidney - metabolism
Lead Poisoning - diagnosis
Lead Poisoning - veterinary
Liver - drug effects
Liver - metabolism
Pregnancy
Stomach - drug effects
Tissue Distribution
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Summary:Lead (Pb) intoxication in horses is usually a chronic phenomenon with clinical signs associated with central nervous dysfunction. This report gives details of a case of acute Pb intoxication in a 9-year-old American Saddlebred mare with severe, progressive and ultimately fatal neurological deterioration. During the 4 days of hospitalisation, clinical signs progressed from intermittent headshaking and depression to severe, continuous, uncontrollable manic behaviour. At autopsy, three grey-coloured, hard metal particles were present in the gastrointestinal tract and subsequently found to contain 2614 ppm Pb. Lead concentrations in the brain, liver, stomach and kidney were 29, 4, 6 and 2 ppm wet weight, respectively.
ISSN:1019-9128