Too many ends: aberrant transposition

A recent study by Zhang and colleagues published in the March 15, 2009, issue of Genes & Development (pp. 755-765) demonstrates that maize Ac/Ds transposons mediate translocations and other rearrangements through aberrant execution of the normal transposition process. Ac transposase uses one end...

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Bibliographic Details
Published inGenes & development Vol. 23; no. 9; pp. 1032 - 1036
Main Author Weil, Clifford F
Format Journal Article
LanguageEnglish
Published United States 01.05.2009
Subjects
Animals
DNA Transposable Elements - genetics
Gene Rearrangement - genetics
Humans
Translocation, Genetic - genetics
Transposases - metabolism
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Summary:A recent study by Zhang and colleagues published in the March 15, 2009, issue of Genes & Development (pp. 755-765) demonstrates that maize Ac/Ds transposons mediate translocations and other rearrangements through aberrant execution of the normal transposition process. Ac transposase uses one end from each of two neighboring elements in these events, which may happen more commonly than previously thought. In genomes where there can be many transposon ends scattered across all the chromosomes, such mistakes can have important consequences.
Bibliography:ObjectType-Article-1
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content type line 23
ISSN:1549-5477
DOI:10.1101/gad.1801309