The analysis of monomer sequences in protein and tRNA and the manifestation of the compensation of pathogenic deviations in their evolution

The sequence analysis of proteins and mitochondrial tRNA indicated that substitutions inducing the pathogenesis in humans often occur in normal individuals of other species having no signs of pathology. The analysis of the structural stability of the protein and tRNA molecules showed that the harmfu...

Full description

Saved in:
Bibliographic Details
Published inBiofizika Vol. 50; no. 3; p. 389
Main Author Kondrashov, F A
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.05.2005
Subjects
Animals
Base Sequence
Evolution, Molecular
Genetic Diseases, Inborn - genetics
Humans
Point Mutation
Proteins - genetics
RNA, Transfer - genetics
Online AccessGet more information

Cover

More Information
Summary:The sequence analysis of proteins and mitochondrial tRNA indicated that substitutions inducing the pathogenesis in humans often occur in normal individuals of other species having no signs of pathology. The analysis of the structural stability of the protein and tRNA molecules showed that the harmful effect of pathogenic substitutions is often neutralized by other compensatory substitutions, which restore the required normal stability of the structure. A further study of this phenomenon will probably lead to new methods of treatment of genetic pathology, which would be based not on the correction of one substitution but on the correction of the stability of the molecule as an entire functional unit.
ISSN:0006-3029