Pharmacokinetics and pharmacodynamics of mivacurium in patients phenotypically homozygous for the atypical plasma cholinesterase variant : Effect of injection of human cholinesterase

• Published in: Anesthesiology (Philadelphia) Vol. 102; no. 6; pp. 1124 - 1132
• Main Authors: ØSTERGAARD, Doris, VIBY-MOGENSEN, Jørgen, RASMUSSEN, Søren N, GÄTKE, Mona R, VARIN, France
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott 01.06.2005
• Subjects: Adolescent; Adult; Anesthesia; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Cholinesterases - administration & dosage; Cholinesterases - blood; Cholinesterases - genetics; Female; Genetic Variation - genetics; Homozygote; Humans; Isoquinolines - blood; Isoquinolines - pharmacokinetics; Isoquinolines - pharmacology; Male; Medical sciences; Middle Aged; Mivacurium; Phenotype; Human; Enzyme; Hydrolases; Anesthesia; Esterases; Homozygosity; Pharmacokinetics; Cholinesterase; Carboxylic ester hydrolases
• ISSN: 0003-3022; 1528-1175
• DOI: 10.1097/00000542-200506000-00011

In patients homozygous for atypical plasma cholinesterase, mivacurium causes a long-lasting neuromuscular block, but injection of human cholinesterase has been proven effective in antagonizing the block. The purpose of this study was to evaluate the pharmacodynamics and pharmacokinetics of mivacurium in such patients, as well as the effect of cholinesterase injected early or late after mivacurium. Eleven patients phenotypically homozygous for the atypical variant received 0.075 mg/kg (1 patient) or 0.15 mg/kg (10 patients) mivacurium. The neuromuscular block was monitored using train-of-four nerve stimulation and mechanomyography. Cholinesterase, 2.8-10.0 mg/kg, was administered approximately 30 or 120 min after mivacurium. The times to different levels of neuromuscular recovery and the venous concentrations of the isomers of mivacurium were measured. Injection of cholinesterase increased plasma cholinesterase activity to normal and the clearances of the active isomers and the elimination rate constants by a factor of 10-15. The first response was seen in 13.5 min (3.7-44.2 min). Time to a train-of-four ratio of 0.8 ranged from 30 to 60 min (n = 6). Neostigmine injected after cholinesterase shortened recovery further, and a train-of-four ratio of 0.8 was reached in 10-30 min. As expected, the duration of action of mivacurium is markedly prolonged in homozygous atypical patients. Injection of cholinesterase significantly increases the metabolism of mivacurium, leading to a shorter duration of action. Injection of neostigmine after the administration of cholinesterase speeds up recovery.