Does dipyridamole-induced ischaemia affect NT-proBNP secretion?

Background: B-type natriuretic peptide (BNP) and the inactive amino-terminal pro-B-type natriuretic peptide (NT-proBNP) have a prognostic value in heart failure and in myocardial infarction. There has been some evidence that BNP and NT-proBNP can be used in the diagnosis of myocardial ischaemia by i...

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Published inCardiovascular Journal of Africa Vol. 18; no. 6; pp. 371 - 374
Main Authors Vangu, Mboyo-Di-Tamba, Perumal, Nalini, Libhaber, Elena, Govender, Radha, Vermaak, William, De Greef, Jacques
Format Journal Article
LanguageEnglish
Published South Africa Clinics Cardive Publishing 01.11.2007
Subjects
Adult
Aged
Aged, 80 and over
Biomarkers - blood
Cardiovascular Topics
Dipyridamole
Exercise Test
Female
Humans
Male
Middle Aged
Myocardial Ischemia - chemically induced
Myocardial Ischemia - diagnosis
Natriuretic Peptide, Brain - secretion
Peptide Fragments - secretion
Technetium Tc 99m Sestamibi
Tomography, Emission-Computed, Single-Photon
Vasodilator Agents
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Summary:Background: B-type natriuretic peptide (BNP) and the inactive amino-terminal pro-B-type natriuretic peptide (NT-proBNP) have a prognostic value in heart failure and in myocardial infarction. There has been some evidence that BNP and NT-proBNP can be used in the diagnosis of myocardial ischaemia by improving the sensitivity of exercise-stress testing. Objective: To observe the relationship between dipyridamole-induced ischaemia and the secretion of NT-proBNP. Methods: A total of 52 consecutive patients, referred for dipyridamole stress 99mTc-sestamibi single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) to diagnose reversible ischaemia, were enrolled. NT-proBNP was determined at rest and one hour after infusion of dipyridamole. Results: Of the 52 patients, 25 had normal scans, 12 had scans with fixed defects (previous myocardial infarction with no inducible ischaemia) and 15 had reversible perfusion defects (inducible ischaemia). There was no correlation between ischaemia and resting NT-proBNP, post-stress NT-proBNP and the change in NT-proBNP. There was a correlation between ejection fraction, ventricular volumes and resting NT-proBNP. Conclusions: NT-proBNP does not add to the diagnosis of myocardial ischaemia in dipyridamole stress MPI.
ISSN:1995-1892
1680-0745