Acute lymphoblastic leukemia in infants

Between January 1978 and August 1999, 29 infants with newly diagnosed acute lymphoblastic leukemia (ALL) were treated on three consecutive protocols. Eighteen patients with infant ALL diagnosed between 1978-1991 were included in Group 1. In this group, treatment comprised a two- or three-drug induct...

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Published inTurkish journal of pediatrics Vol. 46; no. 2; pp. 115 - 119
Main Authors Gürgey, Aytemiz, Yetgin, Sevgi, Cetin, Mualla, Gümrük, Fatma, Tuncer, A Murat, Tunçbilek, Ergül, Hiçsönmez, Gönül
Format Journal Article
LanguageEnglish
Published Turkey 01.04.2004
Subjects
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Asparaginase - administration & dosage
Disease-Free Survival
Female
Follow-Up Studies
Humans
Infant
Male
Methylprednisolone - administration & dosage
Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality
Prednisolone - administration & dosage
Recurrence
Retrospective Studies
Survival Analysis
Survival Rate
Treatment Outcome
Vincristine - administration & dosage
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Summary:Between January 1978 and August 1999, 29 infants with newly diagnosed acute lymphoblastic leukemia (ALL) were treated on three consecutive protocols. Eighteen patients with infant ALL diagnosed between 1978-1991 were included in Group 1. In this group, treatment comprised a two- or three-drug induction with prednisolone, vincristine and L-asparaginase, and maintenance therapy consisted of weekly oral administration of mercaptopurine and methotrexate for three years. Group 2: Between 1991 and 1999, 11 infants with ALL were treated by St. Jude Total Therapy XI (n=4) and XIII (n=7) protocols with minor modification. Three years' event-free survival (+/-SE) was 14 +/- 9% in group 1. In group 2, this rate was 25 +/- 22% in Total XI and 57 +/- 19% in Total XIII. Outcome for infants on protocols Total Therapy XI and XIII improved compared with that of group 1.
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ISSN:0041-4301