Poorly Controlled New-Onset Diabetes Mellitus and Other Atypical Signs as an Early Sign of Pancreatic Adenocarcinoma

A 50-year-old man presented with poorly controlled new-onset diabetes mellitus. Six months after diagnosis, episodes of intense abdominal pain with vomiting appeared. Abdominal CT revealed signs of acute pancreatitis with structural changes in the pseudocysts. In the absence of biliary lithiasis or...

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Published inCurēus (Palo Alto, CA) Vol. 16; no. 6; p. e62319
Main Authors Cordero Pérez, Francisco Josué, Rodríguez López, Pablo, Oleaga Gómez, Paula, Antona Herranz, Marta, Martín Garrido, Eva Purificación
Format Journal Article
LanguageEnglish
Published United States Cureus Inc 01.06.2024
Subjects
Abdomen
Case reports
Cellular biology
Cysts
Diabetes
Medical diagnosis
Medical imaging
Oncology
Pain
Pancreatic cancer
Pancreatitis
Patients
Phosphatase
Thrombosis
Tumors
Ultrasonic imaging
acute pancreatitis complications
pancreatic pseudocyst (ppc)
adenocarcinoma pancreas
new-onset diabetes
acute pancreatitis (ap)
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Summary:A 50-year-old man presented with poorly controlled new-onset diabetes mellitus. Six months after diagnosis, episodes of intense abdominal pain with vomiting appeared. Abdominal CT revealed signs of acute pancreatitis with structural changes in the pseudocysts. In the absence of biliary lithiasis or a toxic etiology of acute pancreatitis, the patient progressed unfavorably with increased abdominal pain and fever. Control imaging tests (two and 10 months later) showed the evolution of phlegmonous/necrotic collections, together with portal vein thrombosis and splenomegaly. Given the suggestive signs of possible occult malignancy, such as portal thrombosis, histological analysis of the ascitic fluid revealed a pancreatic adenocarcinoma. Despite the initiation of chemotherapy, the patient died 12 months after diagnosis.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-1
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ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.62319