Effect of crystal form on in vivo topical anti-inflammatory activity of corticosteroids

The aim of this study was to gain information on the effects of the crystal form of corticosteroids on the topical anti-inflammatory activity. Two different crystal forms, Form A and Form B, of the drugs of prednicarbate, hydrocortisone, betamethasone 17-valerate, prednisolone, and methyl prednisolo...

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Published inArchives of pharmacal research Vol. 25; no. 4; pp. 556 - 559
Main Authors Sohn, Young-Taek, Kim, Sun-Young
Format Journal Article
LanguageEnglish
Published Korea (South) 01.08.2002
Subjects
Administration, Topical
Animals
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - pharmacology
Arachidonic Acid - antagonists & inhibitors
Calorimetry, Differential Scanning
Crystallization
Crystallography, X-Ray
Ear, External - pathology
Edema - chemically induced
Edema - pathology
Edema - prevention & control
Male
Mice
Mice, Inbred ICR
Steroids
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Summary:The aim of this study was to gain information on the effects of the crystal form of corticosteroids on the topical anti-inflammatory activity. Two different crystal forms, Form A and Form B, of the drugs of prednicarbate, hydrocortisone, betamethasone 17-valerate, prednisolone, and methyl prednisolone were prepared and their topical anti-inflammatory activities were measured using arachidonic acid induced ear edema assay in mice. Two crystal forms of the drugs showed differences in anti-inflammatory activity. Among the drugs examined, Form B of prednicarbate and betamethasone 17-valerate showed significantly more potent anti-inflammatory activities as compared to their Form A.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0253-6269
DOI:10.1007/BF02976618